Simparica Trio from Zoetis Petcare provides flea, tick and heartworm prevention for dogs, plus targeted intestinal parasite control that lasts for an entire month. Now, you can get full-year protection against fleas and five kinds of ticks, total roundworm and hookworm control, and heartworm prevention with just one tasty, chewable dose a month.
Sarolaner, one of three active ingredients in Simparica Trio, attacks fleas and ticks when they bite your pup, killing them within 24 hours. This prevents flea reinfestation by destroying fleas before they can reproduce, and the month-long protection means any newly hatched fleas die as soon as they try to feed on your dog. It also keeps ticks from passing on dangerous diseases like Lyme by eliminating them before the infection can be transmitted. Simparica Trio kills Gulf Coast, Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. Simparica Trio also prevents heartworms and keeps hookworms and roundworms from harming your pup. Moxidectin stops heartworm larvae from maturing and infecting your dog, while pyrantel treats and helps prevent hookworms and roundworms at the root.
Give your dog the once-a-month oral treatment that combines heartworm and flea prevention for dogs with unparalleled tick coverage and intestinal parasite control. Getting total protection against the pesky pests that plague your pup has never been easier.
Shop Simparica Trio by Your Dog’s Weight on Chewy:
|Color on Box||Weight Range||Strength||Dosage||Product Page|
|Gold||2.8-5.5 lbs||3 mg Sarolaner, 0.06 mg Moxidectin, 12.5 mg Pyrantel||Administer orally once a month||✓-Check Price|
|Purple||5.6-11.0 lbs||6 mg Sarolaner, 0.12 mg Moxidectin, 25 mg Pyrantel||Administer orally once a month||✓-Check Price|
|Caramel||11.1-22.0 lbs||12 mg Sarolaner, 0.24 mg Moxidectin, 50 mg Pyrantel||Administer orally once a month||✓-Check Price|
|Teal||22.1-44.0 lbs||24 mg Sarolaner, 0.48 mg Moxidectin, 100 mg Pyrantel||Administer orally once a month||✓-Check Price|
|Green||44.1-88.0 lbs||48 mg Sarolaner, 0.96 mg Moxidectin, 200 mg Pyrantel||Administer orally once a month||✓-Check Price|
|Brown||88.1-132.0 lbs||72 mg Sarolaner, 1.44 mg Moxidectin, 300 mg Pyrantel||Administer orally once a month||✓-Check Price|
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What is Simparica Trio?
Simparica Trio is a tasty, once-a-month chewable tablet for parasite control in dogs. It contains a combination of three active ingredients—sarolaner, moxidectin and pyrantel—that work together to keep your dog free of fleas, ticks, heartworms and intestinal worms.
How does Simparica Trio work?
Sarolaner kills fleas and ticks when they feed on your dog’s blood. It starts to work immediately and usually kills within 24 hours of a bite. This helps to prevent ticks from passing on diseases like Lyme and also prevents flea infestations. Moxidectin, the heartworm prevention medicine in Simparica Trio, kills heartworms in the larval stage so they can’t mature and endanger your pup. Pyrantel kills hookworms and roundworms in active infections and kills off any newly-introduced ones to provide ongoing protection. It’s comprehensive parasite protection that lasts a whole month.
Is Simparica Trio safe?
The Simparica Trio combo treatment was approved by the FDA and demonstrated safe for puppies as young as 8 weeks and as small as 2.8 pounds. The three active ingredients in it.
Why choose SIMPARICA TRIO on Chewy and Amazon?
- Proven to protect your dog against heartworm disease, ticks & fleas, and roundworms & hookworms in just one monthly dose.
- Tasty chewable that you only need to give once a month: Demonstrated safe for puppies as young as 8 weeks old, weighing 2.8 lbs or more.
Dosage and administration:
For oral use.
Simparica Trio should be administered at a dose of 1.2-2.4 mg/kg of sarolaner, 0.024-0.048 mg/kg moxidectin and 5-10 mg/kg of pyrantel in accordance with the following table.
Method of administration:
Tablets can be administered with or without food.
Simparica Trio tablets are palatable and readily consumed by the majority of dogs when offered by the owner. If the tablet is not taken up voluntarily by the dog it can also be given with food or directly into the mouth. The tablets should not be divided.
The treatment schedule should be based on veterinary diagnosis, the local epidemiological situation and/or the epidemiological situation of other areas the dog has visited or is going to visit. If based on veterinarian opinion re-administration(s) of the product is required, any subsequent administration(s) must follow the minimum 1 month interval schedule.
The product should only be used in dogs when treatment of ticks / fleas and gastrointestinal nematodes is indicated at the same time. In the absence of the risk of mixed co-infestation, a narrower spectrum parasiticide should be used.
Treatment of flea and tick infestations and gastrointestinal nematodes:
The veterinary medicinal product can be used as part of the seasonal treatment of fleas and ticks (replacing treatment with a mono-active flea and tick product) in dogs with diagnosed concurrent gastrointestinal nematode infections. A single treatment is efficacious for the treatment of gastrointestinal nematodes. After treatment of the nematode infections, further flea and tick treatment should be continued with a mono-active product.
Prevention of heartworm disease and angiostrongylosis:
A single administration also prevents lungworm disease (by reducing the immature adults (L5) of A. vasorum) and heartworm disease (D. immitis) for one month. When the product replaces another lungworm or heartworm preventive product, the first dose of the product should be given within a month of the last dose of the former veterinary medicinal product. In endemic areas, dogs should receive lungworm and/or heartworm preventive treatments at monthly intervals. It is recommended that heartworm prevention treatment should be continued until at least 1 month after the last exposure to mosquitoes.
Contra-indications, warnings, etc
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Ticks and fleas need to start feeding on the host to become exposed to sarolaner; therefore, the transmission of infectious parasite-borne diseases cannot be excluded.
This veterinary medicinal product is not effective against adult D. immitis. However, accidental administration to dogs infected with adult heartworms should not pose safety concerns. Dogs in areas endemic for heartworm (or those which have travelled to endemic areas) may be infected with adult heartworms. Maintenance of the efficacy of macrocyclic lactones is critical for Dirofilaria immitis control. To minimise the risk of resistance selection, it is recommended that dogs should be checked for both circulating antigens and blood microfilariae at the beginning of each season of preventative treatment. Only negative animals should be treated.
Parasite resistance to any particular class of parasiticides may develop following the frequent, repeated use of a product of that class. Therefore, the use of this product should be based on the assessment of each individual case and on local epidemiological information about the current susceptibility of the target species in order to limit the possibility of a future selection for resistance.
In the absence of available data, treatment of puppies less than 8 weeks of age and/or dogs less than 1.25 kg bodyweight should be based on a benefit-risk assessment by the responsible veterinarian.
The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed.
The safety of Simparica Trio has not been established during pregnancy and lactation or in dogs intended for breeding. The use in these animals is not recommended.
Wash hands after handling the product.
The accidental ingestion of the product may potentially result in adverse effects, such as transient excitatory neurological signs. To prevent children from accessing the product, only one chewable tablet at a time should be removed from the blister pack and only when required. The blister pack should then be returned into the carton immediately after use and the carton should be stored out of the sight and reach of children. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or label to the physician.